重症医学中心

  • 国家临床重点专科
  • 江苏省重症医学重点实验室
  • 国家重症医学质量控制中心
  • 江苏省重症医学质量控制中心
  • 国家重大疫情救治基地
  • 江苏省重症医学诊疗中心
  • 国家疑难病症诊治能力提升工程

东南大学附属中大医院重症医学科

国家临床重点专科 

2025年论文目录

  1. Liu L, Sun Q, Yang Y, Qiu H, Slutsky AS. Individualized response to awake prone positioning in COVID-19 patients: need deeper insights. Intensive Care Med. 2025 Jan;51(1):239-240.
  2. Xu J, Liu L, Qiu H. The endpoint of fluid responsiveness: is cardiac output enough? Intensive Care Med. 2025 Jul;51(7):1410-1411.
  3. Liu L, Sun Q, Zhao H, Liu W, Pu X, Han J, Yu J, Jin J, Chao Y, Wang S, Liu Y, Wu B, Zhu Y, Li Y, Chang W, Chen T, Xie J, Yang Y, Qiu H, Slutsky A; Chi-ARDS Net (Chinese ARDS Research Network). Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial. Intensive Care Med. 2024 Aug;50(8):1298-1309.
  4. Yuan X, Chen D, Chao Y, Zhang R, Guo L, Xie J, Liu S, Zhao Z, Huang Y, Yang Y, Mauri T, Qiu H, Liu L. Effect of Individualized Positive End-Expiratory Pressure Titrated by Electrical Impedance Tomography in Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2025 Mar;211(3):418-421.
  5. Yuan X, Zhong M, Li Z, Sang L, Huang X, Zhang R, Chen H, Gao Y, Wang Y, Lin Z, Lu S, Yang F, Chen T, Guo L, Xie J, Zhao Z, Huang Y, Yang Y, Mauri T, Qiu H, Liu L; Chi-ARDS Net (Chinese ARDS Research Network). Electrical impedance tomography-guided PEEP and mortality of patients with the acute respiratory distress syndrome: The EITVent randomized clinical trial. Am J Respir Crit Care Med. 2026 Jan 23:aamaf125.
  6. Zhu XX, Li H, Zi SF, Tang Y, Liu N, Li KX, Geng SK, Lu HQ, Xie ZK, Xu XY, Wei YT, Wang LX, Liu T, Chao J, Yang Y, Qiu HB, Huang W, Liu L. tRF-5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome. Adv Sci (Weinh). 2025 Sep;12(33):e03014.
  7. Tan X, Wu X, Sheng R, Tao Y, Li W, Liang Y, Gui B, Lu H, Feng D, Chen N, Liu F, Liu L, Ge L. Microbubble-Templated Immunoactive Metal-Phenolic Capsules for Drug Delivery and Enhanced Cancer Immunotherapy. Research (Wash D C). 2025 Jul 4;8:0752.
  8. Wu X, Liu S, Hu W, Peng Q, Huang W, Ding J, Huang Y, Qiu H. From Defense to Dysfunction: Decoding the Paradox of Emergency Granulopoiesis in Sepsis Pathogenesis. Research (Wash D C). 2025 Dec 23;8:1011.
  9. Lou X, Chen H, Shi N, Yu R, Li S, Yang Y, Liu S, Xie J, Qiu H. Treatment effects of Xuebijing injection in patients with sepsis by clinical phenotype: a post hoc analysis of the EXIT-SEP trial. EClinicalMedicine. 2025 Jul 9;86:103341.
  10. Wang C, Qi Y, Zhu G, Yang Y, Xie J, Qiu H. A new perspective of simultaneous exposure of risk factors to explore the role of ambient temperature associated with mortality. Environ Int. 2025 Dec;206:109968.
  11. Hu Z, Chen Y, Xu L, Guo L, Li Y, Mo M, Xu J, Li X, Zhu Y, Hong X, Wang H, Liu S. Timing of ceiling lift-assisted out-of-bed sitting training and outcomes in critically ill patients: a prospective cohort study. Crit Care. 2025 Nov 17;29(1):493.
  12. Kang J, Hu D, Li Y, Ma L, Chen H, Xie J, Yang Y, Yang T, Feng Z, Liu Y, Qiu H, Liu S, Zhang C. Xuebijing injection reduces 28-day mortality in patients with septic shock. Crit Care. 2025 Oct 6;29(1):419.
  13. Hu Z, Pu X, Tang R, Zhou M, Liu W, Li J, Cui M, Zhu Y, Yu T, Yu J, Ma X, Ge H, Xu Q, Wang Y, Ou J, Guan Z, Chen T, Yuan X, Zheng M, Wang H, Yang Y, Qiu H, Chen H, Liu L; Chinese ARDS Research Network. Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness: A Multicenter Randomized Controlled Trial. Chest. 2025 Sep 20:S0012-3692(25)05263-8.
  14. Xie Y, Yan Y, Hong Q, Zheng H, Cao L, Li X, Liu S, Chen H. Heterogeneous treatment effects of stress ulcer prophylaxis among ICU patients at risk for gastrointestinal bleeding. BMC Med. 2025 Apr 7;23(1):206.
  15. Li W, Liang Y, Tan X, Chen N, Feng D, Wu X, Liu L, Ge L. Self-Powered Microneedle Patch with Synergistic Mild Microwave Thermal Therapy for Scarless Healing of Infected Diabetic Wound. ACS Appl Mater Interfaces. 2025 Nov 19;17(46):62936-62956.
  16. Zhang S, Wei M, Luan C, Gao B. Bioinspired wearable polymer microneedle patches: pioneering diabetic wound therapy for the horizon. RSC Adv. 2025 Sep 8;15(39):32509-32535.
  17. Wang J, Meng S, Chen Y, Wang H, Hu W, Liu S, Huang L, Xu J, Li Q, Wu X, Huang W, Huang Y. MSC-mediated mitochondrial transfer promotes metabolic reprograming in endothelial cells and vascular regeneration in ARDS. Redox Rep. 2025 Dec;30(1):2474897..
  18. Chen H, Qiu H. Acute respiratory distress syndrome: Rethinking and research priorities. Chin Med J (Engl). 2025 Jul 5;138(13):1516-1518.
  19. Xue M, Zhou Z, Xie J. Does Empirical Antifungal Therapy Reduce IAPA in Influenza-Associated ARDS? Methodological Concerns on Diagnosis, Surveillance, and Clinical Heterogeneity. Clin Infect Dis. 2025 Dec 5:ciaf661.
  20. Sun Q, Teng R, Shi Q, Liu Y, Cai X, Yang B, Cao Q, Shu C, Mei X, Zeng W, Hu B, Zhang J, Qiu H, Liu L. Clinical implement of Probe-Capture Metagenomics in sepsis patients: A multicentre and prospective study. Clin Transl Med. 2025 Apr;15(4):e70297.
  21. Tang Z, Sun Q, Xu J, Yang Y, Peng F. Comparison of Esmolol Versus Landiolol on Mortality in Adult Patients With Sepsis: A Systematic Review and Network Meta-Analysis. Crit Care Med. 2026 Feb 1;54(2):324-334.
  22. Yang N, Li W, Qian Z, Tan X, Liu Z, Feng F, Liu L, Ge L. Trident-inspired fucoidan-based armor-piercing microcapsule for programmed acute pulmonary embolism treatment. Colloids Surf B Biointerfaces. 2025 Jan;245:114323.
  23. Jiang L, Chen H, Chang W, Sun Q, Yuan X, Wu Z, Xie J, Liu L, Yang Y. Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome. Ann Intensive Care. 2025 Jan 13;15(1):6.
  24. Sun Q, Zhang R, Zhang J, Xie J, Huang Y, Yang Y, Qiu H, Liu L, Chen H; Chi-ARDS Net (Chinese ARDS Research Network). Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial. Ann Intensive Care. 2025 Jun 23;15(1):84.
  25. Gao C, Lu X, Jiang Y, Tang Y, Ni Y, Chen H, Wu X, Zhou X, Yang Y, Liu L, Chao J, Xie J, Qiu H. Development of a gene panel for immune status assessment in sepsis. Ann Intensive Care. 2025 Oct 27;15(1):170.
  26. Sun Q, Chen H, Yang Y, Qiu H, Liu L. Refining APP strategies in COVID-19: balancing efficacy, feasibility, and individual needs. Ann Intensive Care. 2025 Aug 11;15(1):118.
  27. Guo J, Meng S, Zhang J, Wang N, Guo F. Zn2+ regulates mitochondrial DNA efflux to inhibit AIM2-mediated ZBP1-PANoptosome pathway and alleviate septic myocardial injury. Chem Biol Interact. 2025 Aug 25;417:111525.
  28. Peng Q, Li Q, Xiong M, Bi M, Hu L, He J, Zhong S, Liu S, Wang H, Zhang C, Xie J, Huang Y. Optimizing Polymyxin B Therapy in Critical Care: Pharmacokinetic Insights and Clinical Outcomes in a Retrospective Cohort Study. Infect Dis Ther. 2025 Nov;14(11):2565-2582.
  29. Liu L, Chen S, Zhu Y, Hu D, Jin C, Wu J, Fu H, Liu S, Zheng H, Hao T, Wu C, Liu A, Liu S. Red blood cell transfusion threshold in patients receiving Venovenous extracorporeal membrane oxygenation-A meta-analysis. J Clin Anesth. 2026 Jan;108:112065.
  30. Yang S, Sun Q, Yuan X, Wang J, Wang H, Hu W, Peng Q, Zhang C, Li X, Huang W, Xie J, Guo F, Liu L, Yang Y, Huang Y. Effect of prone position on ventilation-perfusion matching in patients with moderate to severe ARDS with different clinical phenotypes. Respir Res. 2025 Feb 28;26(1):70.
  31. Chen S, Liu L, Hu D, Zhu Y, Wu C, Fu H, Wu J, Zhang K, Chang M, Hao T, Wang W, Liu S. Effect of artificial intelligence in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Intensive Crit Care Nurs. 2026 Feb;92:104165.
  32. Chen G, Li X, Xie J. Risk factors for mucosal membrane pressure injury in the intensive care unit: Future perspectives – Response to Rahimi-Bashar et al. Intensive Crit Care Nurs. 2025 Apr;87:103973.
  33. Mu G, Zhang Y, Zhang J, Cui G, Yuan X, Pan C, Xu J. The predictive value of hyaluronic acid for the severity and prognosis of COVID-19: a retrospective multicenter cohort study. Ann Med. 2025 Dec;57(1):2534849.
  34. Chen G, Shen C, Pan C, Gao X, Sun M, Li X. Summary of best evidence for safe management of vasopressors through peripheral intravenous catheters. BMC Nurs. 2025 Jul 31;24(1):1000.
  35. Yuan S, Yang Z, Li J, Wu C, Liu S. AI-Powered early warning systems for clinical deterioration significantly improve patient outcomes: a meta-analysis. BMC Med Inform Decis Mak. 2025 Jun 2;25(1):203.
  36. Weng S-s, Lin L, Xie J-f, Hu B-c, Ma X-q, Xia J, Jiang Y, Zhou H, Wu X-y, Jin Y-h, Wu G-q, Yang Y, Sun R-H, Yu Y-s, Zhao D-d. Performance of ddPCR-GNB for microbial diagnosis of suspected bloodstream infection due to the four most common gram-negative bacteria: a prospective, multicenter study. Microbiol Spectr. 2025 Apr;13(4):e0101524.
  37. Xu L, Wang J, Yin X, Li Q, Chen H, Wang H, Hu W, Peng Q, Yang S, Meng S, Huang W, Huang Y. The impact of early nutritional support on in-hospital mortality in patients with sepsis caused by bacterial or viral infections: a retrospective cohort study. Eur J Med Res. 2025 Nov 28;30(1):1193.
  38. Sun CL, Zhou SP, Hou LS, Zhan MJ, Wang YP, Zhao HS, Guo FM, Zhou GQ. A novel methodology for measuring global diaphragm thickness by ultrasonography in patients with critical illness: an exploratory pilot study. BMC Med Imaging. 2025 Aug 20;25(1):341.
  39. Qian Z, Zhang R, Wang Y, He H, Geng S, Li Y, Yuan X, Yang Y, Qiu H, Liu S, Liu L. Effect of low bicarbonate substitution solution on CO2 removal rate in the combined system of extracorporeal CO2 removal and continuous renal replacement therapy. Intensive Care Med Exp. 2025 Nov 19;13(1):116.
  40. Liu L, Chen S, Hu D, Zhu Y, Wu C, Liu A, Hao T, Chen L, Jin C, Wu J, Fu H, Liu S, Zheng H, Qiu H, Yang Y, Liu S. VON WILLEBRAND FACTOR IN ECMO: A DYNAMIC MODULATOR OF HEMORRHAGE AND THROMBOSIS. Shock. 2025 Sep 1;64(3):291-302. doi: 10.1097/SHK.0000000000002632. Epub 2025 May 16. PMID: 40663485.
  41. Chen S, Wu C, Zhang Z, Liu L, Zhu Y, Hu D, Jin C, Fu H, Wu J, Liu S. The role of artificial intelligence in aortic valve stenosis: a bibliometric analysis. Front Cardiovasc Med. 2025 Feb 12;12:1521464.
  42. Jiang J, Chen H, Meng SS, Pan C, Xie JF, Guo FM. Early urea-to-creatinine ratio to predict rapid muscle loss in critically ill patients with sepsis: a single-center retrospective observational study. BMC Anesthesiol. 2025 Jan 11;25(1):26.
  43. Cai XE, Ling WT, Cai XT, Yan MK, Zhang YJ, Xu JY. Effect of restrictive fluid resuscitation on severe acute kidney injury in septic shock: a systematic review and meta-analysis. BMJ Open. 2025 Feb 16;15(2):e086367.
  44. Li X, Zhang C, Li J, Chen T, Xie J, Huang Y. Multicentre open-label randomised controlled trial comparing the efficacy and safety of colistin-based combination therapy with the best available therapy for treating hospital-acquired pneumonia or bloodstream infections caused by carbapenem-resistant Enterobacteriaceae (COUNT-CRE): a study protocol. BMJ Open. 2025 Jul 16;15(7):e092157.
  45. Lu X, Yuan X, Chao Y, Wu X, Liu A. The association of plasma homocysteine levels with short-term mortality in sepsis patients: A meta-analysis. Biomol Biomed. 2025 Mar 7;25(4):786-797. doi: 10.17305/bb.2024.11259. PMID: 39484786; PMCID: PMC11959389.
  46. Meng S, Li X, Chen Y, Xie J, Yang Y, Guo F. Mechanisms and Impact of Sleep Disturbance in Critical Illness: A Review. J Intensive Care Med. 2025 Jul 16:8850666251359203.
  47. Xu J, Wang Y, Shu C, Chang W, Guo F. Dexmedetomidine Improves Microcirculatory Alterations in Patients With Initial Resuscitated Septic Shock. J Intensive Care Med. 2025 Feb;40(2):137-144.
  48. Sun C, Yuan K, Yang N, Hou L, Zhao H, Chen H, Meng S, Guo F. Combined Ultrasound Measurements of Diaphragm and Intercostal Muscles in Mechanically Ventilated Patients with Sepsis: A Novel Approach to Optimize Extubation Prediction. J Intensive Care Med. 2025 Oct 23:8850666251387648.
  49. Mu G, Xu R, Wang Y, Pan C, Xie J. Inserting a VA-ECMO cannula through an inferior vena cava filter during extracorporeal cardiopulmonary resuscitation. Int J Emerg Med. 2024 Dec 18;17(1):188.
  50. Xie J, Han L, Ouyang Y, Liu S, Liang Z, Xi Y, Chen X, Wang Y, Li J, Liu Y, He Y, Li J, Zhao L, Yang L, Lai W, Shang Y, Liu L, Liu X, Li Y, Xu Y. Development and validation of a predictive model for continuous renal replacement therapy in patients undergoing venovenous extracorporeal membrane oxygenation. J Thorac Dis. 2025 Oct 31;17(10):7559-7570.
  51. Lu Jia, Ying Tang, Jianfeng Xie. Alveolar IL1β+ neutrophils: Emerging biomarkers and therapeutic targets in CARDS progression. Clinical and Translational Discovery, 2025, 5(5): e70092
  52. Sun C, Zhan M, Yu L, Li T, Zhao H, Gu Q, Zhou G, Guo F. Respiratory muscle ultrasound echo characteristics and weaning outcomes in mechanically ventilated patients with sepsis: A prospective observational study. Am J Med Sci. 2025 Aug;370(2):189-198.

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